• Heterocyclic and macrocyclic chemistry
o Nucleosides, nucleotides, phosphoramidites, and nucleic acids
• Total synthesis of natural products
o antitumor antibiotics
o DNA-cleaving agents
• Carbohydrates
• Amino acids, peptides, glycopeptides
• Organo-phosphorus and organo-sulfur derivatives
• Pro-drugs
• Organic flame retardants