We conduct drug metabolism, pharmacokinetics (PK) and toxicokinetic (TK) studies in vitro & in vivo to evaluate drug properties.  Our services are recognized as FDA/SFDA compliant.

Services/Capabilities:

• Routine pharmocokinetic (PK) and toxicokinetic (TK) studies in rats, beagle dogs, and monkeys

• Absorption, tissue distribution, and excretion

• Metabolite profiling, identification, and characterization

• Drug interaction (CYPs, UGTs, and transporters)

• Plasma protein binding

• Metabolic stability

• Bioavailability in animals

Available Biological Models

• Caco-2, Bcap37/MDR1, MDCK/MDR1, K562 and K562/ADR cell lines  

• Fluorometric CYP isoforms inhibition assays (1A2, 2C9, 2D6, 2E1, 3A4 etc)

• Recombinant Drug Metabolizing Enzymes (CYP: 1A2, 3A4, 2A5, 2A6, 2A13, 2B6, 2C9, 2C18, 2C19, 2D6, 2E1 etc, and UGT: 1A1, 1A3, 1A4, 1A6, 1A9, 2B7, 2B15 etc)

• Hepatic microsome and primary cultured hepatocytes (human, monkey, rat)

• PXR and CAR Reporter Gene Assays

• In situ single-pass intestinal perfusion (SPIP) and perfusing ligated intestinal segment models